FDA Makes Its Case for Mandatory GRAS: ‘We Lack a Complete Understanding’ of What’s in Food

In a webinar on its proposed rule, FDA said voluntary GRAS leaves it without a full picture of the food supply. Comments close December 9.

In a webinar on its proposed rule, FDA said voluntary GRAS leaves it without a full picture of the food supply. Comments close December 9.

Better Dairy has self-affirmed GRAS status for lactopontin, its yeast-made, human-identical osteopontin, and plans to notify the FDA next year.

FDA finalized identity and safety sections of its NDI guidance and is reexamining the dietary substance definition that governs novel ingredients.

GLP-1 drug users are driving supplement demand for nutrient gaps, digestion, muscle, beauty and weight maintenance after stopping treatment.

CRN CEO Steve Mister supports more transparency for self-affirmed GRAS ingredients, but warns that FDA review of every new ingredient could create a backlog the agency cannot clear.

Supplement industry regulatory oversight intensified in early 2026, with MAHA priorities driving FDA modernization, state legislation, and mounting litigation pressure.

Over 180 NPA members hit Capitol Hill in 2026, pushing for dietary supplement regulatory access via HSAs, FSAs, and drug preclusion reform.